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Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review. Madonna D, Delvecchio G, Soares JC, Brambilla P. In agreement with this context, the present issue of the Brazilian Journal of Psychiatry publishes a systematic review of brain imaging studies in patients with generalized anxiety disorder (GAD). Selecting the optimal treatment for a specific patient would reduce individual and social costs. Moreover, a better understanding of the disorders themselves, their pathological pathways, biomarkers, and clinical aspects (risk factors and predictors of response) may help develop treatments that are more effective. Advances in neurosciences and studies designed to understand the mechanisms and biomarkers associated with these disorders may help guide personalized treatment approaches. Very little evidence is available to guide treatment selection (CBT, selective serotonin reuptake inhibitors, or a combination thereof) for the individual patient.
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Those patients with residual symptoms tend to experience a waxing and waning pattern of recurrence, leading to a chronic course. Remission in CBT for adult anxiety disorders: a meta-analysis. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. Katzman MA, Bleau P, Blier P, Chokka P, Kjernisted K, Van Ameringen M, et al. Despite the many available treatments, which include antidepressants and cognitive behavioral therapy (CBT), 4 4. Quality of life in individuals with anxiety disorders. Those affected with anxious symptoms have a lower quality of life and poorer psychosocial functioning. The global burden of anxiety disorders in 2010. Baxter AJ, Vos T, Scott KM, Ferrari AJ, Whiteford HA. According to the Global Burden of Disease Study, anxiety disorders are the sixth leading cause of disability worldwide, and even mild syndromes are associated with impairment and distress. Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization’s World Mental Health Survey Initiative. Kessler RC, Angermeyer M, Anthony JC, DE Graaf R, Demyttenaere K, Gasquet I, et al. Anxiety disorders are the most prevalent mental disorders.